Washington, Nov 9 : Researchers from the University of Cambridge, Oxford University and Cancer Research UK, London, have acquired new insight into how the ‘obesity gene’ triggers weight gain in some individuals.
The study, led by Professor Stephen O’Rahilly, on the part of the Cambridge collaboration, found that the FTO gene, codes for an enzyme that could act directly on DNA to modify it, suggested that it might have a role in controlling the turning on and off of other genes.
The study also found that FTO was highly expressed in a region of the brain, called the hypothalamus, which has important roles in the control of hunger and satiety and that, in certain parts of the hypothalamus, the levels of FTO were influenced by feeding and fasting.