Rome - Young Argentine Mauro Zarate scored the winner for Lazio Saturday as the side from the capital won 1-0 away to Genoa in a Serie A weekend opener.
The defeat, which they suffered after a four-win run topped by a 3-2 success at Juventus, could be crucial for Genoa in the race for a fourth available Champions League berth.
Fifth-placed Fiorentina trail Genoa two points adrift and can leapfrog them when they play Sunday at Udinese.
The hosts had their best chances in the early minutes through a header from defender Giuseppe Biava that Fernando Muslera incredibly managed to slap away.