More stable DNA origami is possible

According to a new study, it is possible to fold DNA into different nanoscale mesh structures, which are more stable than earlier iterations of this kind of origami. The study has been conducted by researchers from Sweden's Karolinska Institute and their colleagues.

According to Tim Liedel, an experimental physicist at Ludwig Maximilians University Munich who was not related to the study, "This is not the first study to present polygon meshes constructed from DNA-decades of research have produced dozens of methods for building DNA-based polyhedral and wireframe structures. But the current work arguably presents the most versatile and streamlined design method".

The researchers came up with an automated algorithm that finds scaffold sequence along structural targets in order to achieve the more-stable DNA origami structures. Study coauthor Björn Högberg of the Karolinska told that the learning curve is in fact quite improved here and now, it is not difficult to design them.

Scientists have found a better method in order to build small 3D structures from strands of DNA. They calculated the most efficient way to fold nearly any given shape out of a continuous strand by making use of an approach from computer science.

After that, they made use of the principles of "DNA origami" to "staple" the joins using hundreds of shorter strands. The structures are quite stable so much so that they could be used to create microscopic biomedical contraptions. The study was published in the journal Nature on July 22.