Washington, Nov 25 : Scientists have identified a promising new target for the development of a new class of cholesterol lowering drugs.

They have found that the degradation by PCSK9 of the LDLR receptor, which is responsible for removing the bad cholesterol (LDL-cholesterol) from the bloodstream, could be inhibited by a third protein, annexin A2.

This major discovery was made by the team of Dr. Nabil G. Seidah, Director of the Biochemical Neuroendocrinology Research Unit at the IRCM.

Previous studies have shown that PCSK9 is a prime therapeutic target for the prevention and treatment of cardiovascular diseases.

London, Nov 25 : ‘Twilight’, a fantasy romance in which a girl falls in love with a vampire, has set a new record for the biggest opening weekend for a female- directed film, taking 70.6 million dollars.

The film, which topped the North American box office, is directed by Catherine Hardwicke and is based on the first of a series of novels written by US author Stephenie Meyer.

London, Nov. 25 : Manchester United coach Alex Ferguson says that he will always remember the night he stood up his hero Frank Sinatra.

The Manchester United manager had a London dinner date with Ol’ Blue Eyes himself but cancelled after seeing his Reds crash to a shock defeat against Charlton in April 1989.

Ferguson was so incensed by the 1-0 loss at Selhurst Park he bombed out the legendary crooner to start an immediate inquest on the coach back to Manchester.

It is an example of the passion that has kept him at the top for over 20 years.

London, Nov. 25: Manchester City has announced that it is ready to pay 20 million pounds to secure the services of Chelsea star Ashley Cole.

London, November 25 : Amy Winehouse has again landed in hospital after a drink and drug spree set off by a screaming row with hubby Blake Fielder-Civil, according to sources.

The ‘Rehab’ singer, who has made frequent trips to hospitals following her drink and drug addictions, had reportedly collapsed with a seizure and hurried to a London clinic following a heated argument with her hubby over the phone.

London, Nov.