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New York [US], Sept. 23 : The Syrian army has announced a major new offensive on rebel-held eastern Aleppo after international powers with a stake in country's civil war failed to revive a collapsed ceasefire during diplomatic talks in New York.

The offensive was announced as the US Secretary of State, John Kerry, met his Russian counterpart, Sergey Lavrov, and other foreign ministers on the margins of a United Nations summit in New York.

Kerry declared "we cannot continue on the same path any longer" but said he had given Russia another chance to come up with "immediate and significant steps" to stop violence, including the end of Russian and Syrian government bombing of opposition areas.

Beijing [China], Sept.

Islamabad [Pakistan], Sept. 22 : The Pakistan Ministry of Foreign Affairs (MoFA) on Thursday rejected the Indian authorities' blaming Islamabad for the Uri terror strike as "unfounded, baseless and uninvestigated" accusations.

"Minutes after the attack, the Indian authorities blamed Pakistan for the incident without even investigating the matter. I would like to refer you to Adviser Sartaj Aziz's recent statement that 'it is either a strategy or a matter of habit on their part to blame Pakistan for any incident in India, especially in the Kashmir Valley'. We totally reject these unfounded, baseless and uninvestigated accusations levelled against Pakistan," said MoFA spokesperson Nafees Zakaria during a weekly media briefing.

Washington D.C. [USA], Sept. 23 : Ever since its genesis in 2007, American television sitcom, The Big Bang Theory has continued to mainstream everywhere.

The annual Forbes list for the top earning TV actors of 2016 went to all four male casts from 'The Big Bang Theory' with Jim Parsons, for a whopping 25.5 million dollars, securing the No.1 spot yet again, reports E! Online.

Johnny Galecki snagged the No. 2 spot with 24 million dollars, Simon Helberg came in third with 22.5 million dollars, and British Indian actor, Kunal Nayyar is No. 4 with 22 million dollars.

Other actors featured on the list are Mark Harmon of NCIS, Modern Family's Eric Stonestreet, Jesse Tyler Ferguson, Ty Burrell and Ed O'Neill, Kevin Spacey, Nathan Fillion and more.

Shillong [India], Sept. 23 : EmergE, the flagship entrepreneurship summit of the Indian Institute of Management (IIM) - Shillong, is one of the most premier annual events in the northeast.

With a plethora of competitions, conclaves and workshops, EmergE aims to promote the spirit of entrepreneurship in an area rich in untapped human potential.

The fifth edition of the event was recently held in the Convention Hall of IIM Shillong.

Under the theme 'Emerging Northeast East', a two-day interactive session-cum-workshop on development and entrepreneurship was organized by i-CUBE, the e-cell of IIM Shillong, in collaboration with Rajiv Gandhi Indian Institute of Management (RGIIM), Shillong.

Washington D.C. [USA], Sept.22 : A new research says that smoking leaves its impression on the human genome in the form of DNA methylation, a process by which cells control gene activity.

The new findings suggest that DNA methylation could be an important sign that reveals an individual's smoking history and could provide researchers with potential targets for new therapies.

"These results are important because methylation, as one of the mechanisms of the regulation of gene expression, affects what genes are turned on, which has implications for the development of smoking-related diseases," said author Stephanie J. London, adding, "Equally important is our finding that even after someone stops smoking, we still see the effects of smoking on their DNA."