Logitech, at CES this week, demonstrated the Harmony 1100, which will be successor of the currently available Harmony 1000.
The New Harmony 1100, is dominated by a 3.5 inch touchscreen is quite a dish to look at. However, it should be noted that the device is quite prone to sticks and stalls.
Furthermore, the device also rather dependent on being pointed in the right direction, despite using RF wireless capability that Logitech says "lets you control devices that you keep behind closed doors, even those you can't see."