Tokyo - Tokyo stocks lost more than 2 per cent to close Tuesday trading on fears of swine flu and concerns over the US economy. The benchmark Nikkei 225 Stock Average plunged 232.57 points, or 2.67 per cent, to close at 8,493.77.
The broader Topix index of all first-section issues was also down 21.11 points, or 2.53 per cent, at 811.99.
The market entered positive territory at the end of morning trading on pharmaceutical shares.