Washington, November 7 (ANI): A new study has revealed that the anti-herpes drug acyclovir can slow down HIV infection, but with the risk that treated cells may promote the emergence of multi-drug resistant HIV variants.
Moira McMahon and colleagues at Johns Hopkins used a sensitive infection assay of white blood cells, and observed that acyclovir could directly inhibit HIV replication.
The researchers said that the drug particularly targeted the reverse transcriptase (RT) enzyme, which converts HIV’s RNA into DNA to enable it to replicate.
However, as early as five days after initial infection, a mutant version of HIV (V75I) appeared in the cells, and spread to comprise over 90 per cent of the viral population within 94 days.