Washington, Aug 17 : Top seed Novak Djokovic and second seed Andy Murray crashed out of the quarterfinals at the Cincinnati Masters.

Djokovic lost to local big server John Isner 6-7(5), 6-3, 5-7 Friday night, reports Xinhua.

Murray was defeated 3-6, 4-6 by the sixth seed Tomas Berdych.

Isner will meet Juan Martin Del Potro, and Berdych faces Rafael Nadal in the semifinals Saturday night.(IANS)