Washington, Oct 31 : Researchers at UC Davis Cancer Center have discovered that the HER2 gene itself is the key behind the aggressiveness of HER2-positive breast cancer.
They found that HER2 advances tumour growth by shutting down its own regulator gene, labelled LRIG1 and commonly called "Lig-1".
The new study comes in line with recent research showing that Lig-1 limits the growth-promoting signals of HER2.
Now, the researchers have found that the regulator is significantly suppressed when compared to healthy breast tissue.