Washington, November 5 : Penn State researchers have identified thousands of positions where a molecular “master regulator” is located in DNA to control genes in fat cells.
Dr. Mitchell Lazar, Director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania School of Medicine, has revealed that the master molecule is called PPAR gamma, a target of anti-diabetic drugs.
The drugs bind to PPAR gamma in the nucleus of fat cells, which affects the expression of many genes, about twenty of which were previously known.
The latest study has uncovered about 5,300 additional sites that PPAR gamma targets in fat-cell DNA.