Washington, Feb 28 : Achieving a milestone in the fight against malaria, scientists at Amyris Biotechnologies have produced 25 g/L of amorphadiene, a precursor of the antimalarial agent artemisinin, by using synthetic biology and E. coli fermentations.
It was in 2003 that the production of amorphadiene in E. coli was first described, but the amount produced was low (50 mg/L). The level was increased to 0.5g/L in 2006, but still 50-fold lower than target production levels.
In the new study, researchers have described the interplay of industrial fermentation processes and synthetic biology that achieve the required 50-fold increase in production levels.